Category Archives: Cancer

Doctor Mikhail Blagosklonny’s quest to find solution to aging and cancer

Mikhail Blagosklonny is a scientist who studies cancer and aging. He is also the professor of oncology at the Rosewell Park Cancer Institute based in Buffalo, New York. Blagosklonny is known for his extensive research and study of aging. Due to his knowledge in this field, doctor Blagosklonny recommends a drug known as Rapamycin to be used to prevent aging and as a result, prolong the lifespan of a person.

Rapamycin popularly known as Sirolimus (market name of Rapamune) is a medicinal drug that has been in use for some time in preventing organ transplant rejection. Besides this critical use, Rapamycin can also be used for treating a rare lung infection.

The reasons why doctor Blagosklonny believes that Rapamycin is the perfect as a medicine is that:

  1. Its immunosuppressant properties

After a successful organ transplant, the body may try rejecting the new organ, hence the surgery might fail. For this reason, doctors for a long time have been using anti-rejection drugs such as calcineurin inhibitors, but unfortunately, they have adverse side effects on the kidneys of the patient. Here is where Rapamycin comes in. It has lower toxicity levels as compared to other immunosuppressive drugs.

  1. Used for treating patients suffering from hemolytic

Uremic syndrome – such patients, requires an immediate kidney transplant and there is no guarantee that the new kidney wouldn’t contract the same disease. In such cases, Rapamycin is used as an immunosuppressive drug because of its low toxicity.

  1. Can be used to treat patients with a rare disease known as Lymphangioleiomyomatosis (LMA)

Affects mostly, women.Rapamycin blocks the mTOR gateway that opens due to mutation of Tuberous Sclerosis Complex gene (TSC2).

  1. It is used to treat cancer.

Sirolimus has antiproliferative properties; hence can help the body fight tumors.

  1. Used for coating the coronary stents to prevent re-stenosis in the arteries from happening.
  1. Treatment of Tuberous Sclerosis Complex (TSC)

This congenital infection that can cause a growth of tumors in the brain, kidney, heart, as well as other organs.Rapamycin has been found to reduce the infection in kids and also in adults.

  1. Used for treating Facial angiofibromas

This is an infection that over 80 percent of TSC patients suffer from. It is a kind of rashes that attack the face of the patient. Rapamycin can be used in the form of gel, cream, or even ointments to solve this problem

  1. Increase the lifespan of a person, though still under research.

Doctor Blagosklonny has been in the forefront in research on the subject. So far there is no conclusive evidence that it can prolong the life of a person.

Another potential usage of the drug still under research is;

  • Treatment of Alzheimer’s disorder
  • Treatment of Muscular Dystrophy
  • Treatment of Systemic Lupus Erythematosus (SLE)

Doctor Blagosklonny has been very instrumental in this research to finding treatment for various diseases that affect humans especially cancer and aging. He is trying to prove the fact that cancer is more common to people of certain age. He has been an inspiration to not only his fellow scientists but to students who are learning in the field.

Blagosklonny has a mission to uncover cheap and effective treatment to cancer. He is researching on best ways to remove cancerous cells from the body without affecting healthy body cells.

Eric Lefkofksy is revolutionizing the ways in which oncologists treat cancer

Eric Lefkofsky is best known as the founder of volume discount juggernaut Groupon, an innovative company that allows consumers to form temporary buyer’s coalitions that enable them to get deep volume discounts on their favorite goods. The company has brought billions of dollars to businesses across the globe. It has saved customers even more and more information click here.

But recently, Lefkofsky has embarked on an even greater challenge. Through his latest startup, Tempus, he is seeking to completely transform the ways in which physicians interact with data, allowing for levels of real-time medical analysis that have never before been dreamed of.

Tempus is marrying the power of machine learning with the vast new wealth of data created by such technologies as gene sequencing. In fact, Lefkofsky predicts that, within 10 years, almost everyone will have their entire genome sequenced. This is a direct result of the extreme diminution of cost involved with such an undertaking. Since 2003, the year that the first entire human genome was sequenced, the cost of committing to computer code a person’s entire DNA architecture has dropped from well over $100 million down to just under $5,000. This incredible pace of cost-cutting hasn’t slackened much, either. By 2030, Lefkofksy predicts, the cost of sequencing a person’s full genome will drop to below $100 and learn more about Eric.

What this will do, says Lefkofsky, is create a trove of actionable medical intelligence, the likes of which have never before been seen. The ability of doctors to have, at their fingertips, the entire genomes of every patient who has suffered from a given disease, undergone a given treatment or taken a given drug will allow for an explosion of nuanced understanding in how best to optimize treatment protocols for a patient. In fact, Lefkofksy predicts that in the future, medical treatments will be tailored to the precise genomic makeup of the patient. This will even extend to drugs, which may be synthesized on the spot, leading to different patients with, nominally, the same disease being given radically different courses of treatment, all optimized for their particular genomic makeup and Eric’s lacrosse camp.

Such possibilities are, to say the least, exciting.

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